|
|
Salicylaldehyde + NAD+ + H2O <=> salicylate + NADH + H+
|
1.2.1
1.2.1.24
succinate-semialdehyde dehydrogenase (NAD+)
1.2.1.28
benzaldehyde dehydrogenase (NAD+)
1.2.1.3
aldehyde dehydrogenase (NAD+)
1.2.1.64
4-hydroxybenzaldehyde dehydrogenase (NAD+)
1.2.1.65
salicylaldehyde dehydrogenase
|
–
–
–
–
–
–
|
MK
|
|
BRENDA:
BR29421
KEGG:
R02941
MetaCyc:
1.2.1.65-RXN
SABIO-RK:
6946
|
|
|
|
H+ + salicylate + O2 + NADH <=> catechol + CO2 + H2O + NAD+
|
1.14.13.1
salicylate 1-monooxygenase
|
–
|
MK
|
|
BRENDA:
BR36758
KEGG:
R00818
MetaCyc:
SALICYLATE-1-MONOOXYGENASE-RXN
|
|
|
|
H2O + Acetylsalicylic_acid <=> H+ + acetate + salicylate
|
3.1.1.1
carboxylesterase
3.1.1.55
acetylsalicylate deacetylase
3.1.1.8
cholinesterase
|
–
–
–
|
|
|
BRENDA:
BR48136
KEGG:
R02942
MetaCyc:
ACETYLSALICYLATE-DEACETYLASE-RXN
|
|
|
|
isochorismate <=> salicylate + pyruvate
|
3.3.2.1
isochorismatase
4.2.99.21
isochorismate lyase
|
–
–
|
MK
|
|
BRENDA:
BR49395
KEGG:
R06602
MetaCyc:
RXN-1981
SABIO-RK:
6177
|
|
|
|
salicylate + H+ <=> phenol + CO2
|
4.1.1.46
o-pyrocatechuate decarboxylase
4.1.1.91
salicylate decarboxylase
|
–
–
|
M
|
|
BRENDA:
BR49502
KEGG:
R09539
MetaCyc:
RXN-11736
|
|
|
|
salicylate + O2 + NADH + H+ <=> 2,5-Dihydroxybenzoate + NAD+ + H2O
|
1.14.13.172
salicylate 5-hydroxylase
|
–
|
MK
|
|
BRENDA:
BR50516
KEGG:
R07709
MetaCyc:
RXN-10446
|
|
|
|
S-adenosyl-L-methionine + salicylate <=> methyl_salicylate + S-adenosyl-L-homocysteine
|
2.1.1.273
benzoate O-methyltransferase
2.1.1.274
salicylate 1-O-methyltransferase
|
–
–
|
M
|
|
BRENDA:
BR50620
KEGG:
R10448
MetaCyc:
RXN-6723
|
|
|
|
H+ + salicylate + ATP <=> (2-hydroxybenzoyl)adenylate + diphosphate
|
2.7.7.58
(2,3-dihydroxybenzoyl)adenylate synthase
6.2.1.61
salicylate---[aryl-carrier protein] ligase
6.2.1.65
salicylate---CoA ligase
|
–
–
–
|
M
|
|
BRENDA:
BR53008;
BR53122
KEGG:
R12640
MetaCyc:
RXN-11113
|
|
|
|
ATP + salicylate + CoA <=> diphosphate + AMP + 2-hydroxybenzoyl-CoA
|
6.2.1.17
propionate---CoA ligase
6.2.1.2
medium-chain acyl-CoA ligase
6.2.1.25
benzoate---CoA ligase
6.2.1.65
salicylate---CoA ligase
|
–
–
–
–
|
|
|
BRENDA:
BR53121
KEGG:
R12642
MetaCyc:
RXN-19845
SABIO-RK:
14154
|
|
|
|
methyl_salicylate + H2O <=> H+ + salicylate + methanol
|
3.1.1.1
carboxylesterase
3.1.1.20
tannase
|
–
–
|
M
|
|
BRENDA:
BS363916
MetaCyc:
RXNQT-4366
|
|
|
|
UDP-glucose + salicylate <=> salicylic_acid_7-O-beta-D-glucoside + UDP + H+
|
2.4.1
2.4.1.170
isoflavone 7-O-glucosyltransferase
|
–
–
|
M
|
|
BRENDA:
BS380386
MetaCyc:
RXN-11658
|
|
|
|
2-hydroxybenzoyl-CoA + H2O <=> H+ + salicylate + CoA
|
3.1.2
3.1.2.20
acyl-CoA hydrolase
3.1.2.23
4-hydroxybenzoyl-CoA thioesterase
3.1.2.28
1,4-dihydroxy-2-naphthoyl-CoA hydrolase
|
–
–
–
–
|
M
|
|
BRENDA:
BS398642
MetaCyc:
RXN-2009
|
|
|
|
salicylate + O2 <=> H+ + 2-oxohepta--3,5-dienedioate
|
1.13.11
1.13.11.4
gentisate 1,2-dioxygenase
|
–
–
|
|
|
BRENDA:
BS406638
MetaCyc:
RXN-11748
|
|
|
|
2-hydroxy-6-oxo-6-(2-hydroxyphenyl)hexa-2,4-dienoate + H2O <=> 2-oxopent-4-enoate + salicylate
|
3.7.1
3.7.1.8
2,6-dioxo-6-phenylhexa-3-enoate hydrolase
|
–
–
|
K
|
|
BRENDA:
BS165545
KEGG:
R05360
|
|
|
|
salicylate + NADPH + H+ + O2 <=> 2,5-Dihydroxybenzoate + NADP+ + H2O
|
1.14.13.172
salicylate 5-hydroxylase
|
–
|
K
|
|
BRENDA:
BS422071
KEGG:
R07710
|
|
|
|
o-carboxyphenyl_phosphate + H2O <=> salicylate + phosphate
|
3.1.3.1
alkaline phosphatase
3.1.3.2
acid phosphatase
|
–
–
|
|
|
BRENDA:
BS73552
SABIO-RK:
10631
|
|
|
|
melilotate + ATP + CoA + FAD + NAD+ <=> salicylate + AMP + diphosphate + FADH2 + acetyl-CoA + NADH + H+
|
not assigned
|
–
|
K
|
|
KEGG:
R05537
|
|
|
|
chorismate <=> salicylate + pyruvate
|
not assigned
|
–
|
|
|
KEGG:
R06603
|
|
|
|
2-Hydroxyisophthalic_acid <=> salicylate + CO2
|
4.1.1
|
–
|
K
|
|
KEGG:
R06925
|
|
|
|
2,3-dihydroxynaphthalene <=> salicylate
|
not assigned
|
–
|
K
|
|
KEGG:
R07695
|
|
|
|
benzoate + NADPH + O2 <=> salicylate + NADP+ + H2O
|
1.14.13
|
–
|
K
|
|
KEGG:
R08838
|
|
|
|
2-hydroxy-6-oxo-6-(2-hydroxyphenyl)hexa-2,4-dienoate + H2O <=> (2Z)-2-hydroxypenta-2,4-dienoate + salicylate + H+
|
3.7.1.8
2,6-dioxo-6-phenylhexa-3-enoate hydrolase
|
–
|
M
|
|
MetaCyc:
R608-RXN
|
|
|
|
S-adenosyl-L-methionine + salicylate + L-cysteine + NADPH <=> pyochelin + S-adenosyl-L-homocysteine + NADP+ + H2O
|
not assigned
|
–
|
|
|
MetaCyc:
RXN-11114
|
|
|
|
benzoate + reduced_[NADPH-hemoprotein_reductase] + O2 <=> salicylate + oxidized_[NADPH-hemoprotein_reductase] + H2O
|
1.14.14
|
–
|
|
|
MetaCyc:
RXN-11271
|
|
|
|
UDP-glucose + salicylate <=> salicylic_acid-beta-D-glucoside + UDP
|
2.4.1
|
–
|
M
|
|
MetaCyc:
RXN-11659
|
|
|
|
salicylate + [PmsE_non-ribosomal_peptide_synthase] + ATP <=> salicyl-[PmsE_non-ribosomal_peptide_synthase] + AMP + diphosphate
|
6.2.1.61
salicylate---[aryl-carrier protein] ligase
|
–
|
|
|
MetaCyc:
RXN-19440
|
|
|
|
salicylate + non-ribosomal_peptide_synthase + ATP <=> salicyl-[non-ribosomal_peptide_synthase] + AMP + diphosphate
|
6.2.1.61
salicylate---[aryl-carrier protein] ligase
|
–
|
|
|
MetaCyc:
RXN-19444
|
|
|
|
salicylate + [PchE_non-ribosomal_peptide_synthase] + ATP <=> salicyl-[PchE_non-ribosomal_peptide_synthase] + AMP + diphosphate
|
6.2.1.61
salicylate---[aryl-carrier protein] ligase
|
–
|
|
|
MetaCyc:
RXN-19470
|
|
|
|
salicylate + O2 <=> (2Z,4Z)-6-oxohepta-2,4-dienoate
|
1.13.11.4
gentisate 1,2-dioxygenase
|
–
|
|
|
BRENDA:
BS445879
|
|
|
|
2-hydroxybenzamide + H2O <=> salicylate + NH3
|
3.5.1.4
amidase
|
–
|
|
|
BRENDA:
BS383756
|
|
|
|
salicylate + reduced_flavodoxin + O2 <=> 2,4-Dihydroxybenzoate + flavin + H2O
|
1.14.14.92
benzoate 4-monooxygenase
|
–
|
|
|
BRENDA:
BS289259
|
|
|
|
Salicylaldehyde + O2 + H2O <=> salicylate + H2O2
|
1.17.1.4
xanthine dehydrogenase
1.17.3.2
xanthine oxidase
1.2.3.1
aldehyde oxidase
1.2.3.9
aryl-aldehyde oxidase
|
–
–
–
–
|
|
|
BRENDA:
BS189339
|
|
|
|
o-carboxyphenyl_phosphate + H2O <=> salicylate + phosphate + CO2
|
3.9.1.1
phosphoamidase
|
–
|
|
|
BRENDA:
BS165623
|
|
|
|
Salicylaldehyde + H2O + 2,6-dichlorophenolindophenol <=> salicylate + reduced_2,6-dichlorophenolindophenol
|
1.2.99.7
aldehyde dehydrogenase (FAD-independent)
|
–
|
|
|
BRENDA:
BS374618
|
|
|
|
Salicylaldehyde + ferricyanide + H2O <=> salicylate + ferrocyanide
|
1.17.1.4
xanthine dehydrogenase
|
–
|
|
|
BRENDA:
BS359282
|
|
|
|
n-Propionyl_salicylate + H2O <=> salicylate + propionate
|
3.1.1.1
carboxylesterase
3.1.1.55
acetylsalicylate deacetylase
|
–
–
|
|
|
BRENDA:
BS360639
|
|
|
|
n-Butyryl_salicylate + H2O <=> salicylate + Butyrate
|
3.1.1.55
acetylsalicylate deacetylase
|
–
|
|
|
BRENDA:
BS360640
|
|
|
|
salicylate + NADH + O2 <=> catechol + NAD+ + O2
|
1.14.13.1
salicylate 1-monooxygenase
|
–
|
|
|
BRENDA:
BS377762
|
|
|
|
salicylate + NADH + H+ + O2 <=> catechol + NAD+ + H2O
|
1.14.13.1
salicylate 1-monooxygenase
|
–
|
|
|
BRENDA:
BS419066
|
|
|
|
n-Butyryl_salicylate + H2O <=> 1-butanol + salicylate
|
3.1.1.1
carboxylesterase
|
–
|
|
|
BRENDA:
BS115422
|
|
|
|
Salicylaldehyde + H2O + Oxidized_benzyl_viologen <=> salicylate + H+ + reduced_benzyl_viologen
|
1.2.7.5
aldehyde ferredoxin oxidoreductase
1.2.99.6
carboxylate reductase
1.2.99.7
aldehyde dehydrogenase (FAD-independent)
|
–
–
–
|
|
|
BRENDA:
BS359403
|
|
|
|
n-Pentanoyl_salicylate + H2O <=> salicylate + pentanoate
|
3.1.1.55
acetylsalicylate deacetylase
|
–
|
|
|
BRENDA:
BS360641
|
|
|
|
n-Decanoyl_salicylate + H2O <=> salicylate + Decanoate
|
3.1.1.55
acetylsalicylate deacetylase
|
–
|
|
|
BRENDA:
BS360644
|
|
|
|
n-Octanoyl_salicylate + H2O <=> salicylate + Octanoate
|
3.1.1.55
acetylsalicylate deacetylase
|
–
|
|
|
BRENDA:
BS360643
|
|
|
|
n-Hexanoyl_salicylate + H2O <=> salicylate + hexanoate
|
3.1.1.55
acetylsalicylate deacetylase
|
–
|
|
|
BRENDA:
BS360642
|
|
|
|
n-valeryl_salicylate + H2O <=> 1-Pentanol + salicylate
|
3.1.1.1
carboxylesterase
|
–
|
|
|
BRENDA:
BS115423
|
|
|
|
n-Hexanoyl_salicylate + H2O <=> 1-Hexanol + salicylate
|
3.1.1.1
carboxylesterase
|
–
|
|
|
BRENDA:
BS115424
|
|
|
|
salicylyl-EntB + H2O <=> EntB + salicylate
|
3.1.2.20
acyl-CoA hydrolase
|
–
|
|
|
BRENDA:
BS406641
|
|
|
|
Salicylaldehyde + NADP+ + H2O <=> salicylate + NADPH
|
1.2.1.7
benzaldehyde dehydrogenase (NADP+)
|
–
|
|
|
BRENDA:
BS189310
|
|
|
|
salicylate + O2 + NADPH + 2 H+ <=> catechol + CO2 + H2O + NADP+
|
1.14.13.1
salicylate 1-monooxygenase
|
–
|
|
|
BRENDA:
BS413602
|
|
|
|
2-carboxybenzaldehyde + NADPH <=> salicylate + NADP+
|
1.1.1.274
2,5-didehydrogluconate reductase (2-dehydro-D-gluconate-forming)
|
–
|
|
|
BRENDA:
BS383747
|
|
|
|
salicylate + NADPH + ATP <=> Salicylaldehyde + NADP+ + AMP + H2O
|
1.2.1.30
carboxylate reductase (NADP+)
|
–
|
|
|
BRENDA:
BS189188
|
|
|
|
UDP-glucose + salicylate <=> UDP + 2-(beta-D-glucopyranosyloxy)benzoate
|
2.4.1.35
phenol beta-glucosyltransferase
|
–
|
|
|
BRENDA:
BS322717
|
|
|
|
2-Carboxyphenyl_sulfate + H2O <=> salicylate + sulfate
|
3.1.6.1
arylsulfatase
|
–
|
|
|
BRENDA:
BS93762
|
|
|
|
ethyl_2-hydroxybenzoate + H2O <=> ethanol + salicylate
|
3.1.1.84
cocaine esterase
|
–
|
|
|
BRENDA:
BS405088
|
|
|
|
n-propyl_salicylate + H2O <=> 1-propanol + salicylate
|
3.1.1.1
carboxylesterase
|
–
|
|
|
BRENDA:
BS115421
|
|
|
|
ATP + salicylate + phosphopantetheinylated_EntB <=> arylated_EntB + AMP + diphosphate
|
6.3.2.14
enterobactin synthase
|
–
|
|
|
BRENDA:
BS428397
|
|
|
|
ATP + salicylate + holo-[non-ribosomal_peptide_synthase] <=> AMP + diphosphate + salicyl-[non-ribosomal_peptide_synthase]
|
6.2.1.61
salicylate---[aryl-carrier protein] ligase
|
–
|
|
|
BRENDA:
BR53007
|
|
|
|
ATP + salicylate + holo-[non-ribosomal_peptide_synthase_PchE] <=> AMP + diphosphate + salicyl-[non-ribosomal_peptide_synthase_PchE]
|
6.2.1.61
salicylate---[aryl-carrier protein] ligase
|
–
|
|
|
BRENDA:
BS449621
|
|
|
|
salicylic_acid-beta-D-glucoside + H2O <=> beta-D-glucose + salicylate
|
3.2.1.21
beta-glucosidase
|
–
|
|
|
BRENDA:
BS214478
|
|
|
|
salicylic_acid_7-O-beta-D-glucoside + H2O <=> salicylate + beta-D-glucose
|
3.2.1.21
beta-glucosidase
|
–
|
|
|
BRENDA:
BS411264
|
|
|
|
o-hydroxy-benzonitrile + H2O <=> salicylate + NH3
|
3.5.5.1
nitrilase
|
–
|
|
|
BRENDA:
BS397996
|
|
|
|
salicylate + 3''-Phosphoadenylyl_sulfate <=> Adenosine_3'',5''-bisphosphate + Salicylsulfuric_acid
|
not assigned
|
–
|
|
|
SABIO-RK:
15410
|
|